That means you can control your symptoms with only 1 or 2 doses each day compared with older medications, which usually require doses every 4 to 6 hours to maintain their effectiveness.
The newer antihistamines are available only by prescription.
Short-acting (eg, triazolam) and intermediate-acting (eg, estazolam, temazepam) benzodiazepine receptor agonists are useful for sleep-onset insomnia.
These agents have been the hypnotics of choice for many years because of their relative safety compared with the barbiturates, as well as their low cost.
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Selective melatonin agonists are indicated for insomnia characterized by difficulty with sleep onset, particularly for individuals who lack dim-light melatonin-onset stimulation.
Melatonin itself is not regulated by the US Food and Drug Administration (FDA) and is thus not approved for treatment of insomnia.
A sedative-hypnotic of the pyrazolopyrimidine class, zaleplon has a rapid onset of action and an ultra-short duration of action, making it a good choice for treatment of sleep-onset insomnia.
A second dose can be used during the middle of the night without residual sedation in the morning (this is believed to be an advantage of this hypnotic over others).
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